Structure of PDB 6cta Chain A

Receptor sequence

>6ctaA (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]

GASKLRAVLEKLKLSRDDISTAAGMVNGVVDHLLRRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKNPLSQF
LEGEILSASKMLSKFRKIIKEEINDIDVIMKGGSPAVTLLISEKISVDIT
LALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAQEETWRL
SFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDK
KHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRT
EKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE

3D structure

PDB

6cta Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.

Chain

Resolution

2.779 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S180 A183 N210 Y214 Y215 K384	S20 A23 N50 Y54 Y55 K207
BS02	dna	A	K173 L174 S175 R176 K198 H217 K407	K13 L14 S15 R16 K38 H57 K230
BS03	ZN	A	H390 C397 C404	H213 C220 C227
BS04	MG	A	E225 D227	E65 D67
BS05	ATP	A	G212 S213 E225 D227 R376 S380 E383 K414 S435 Y436 K439	G52 S53 E65 D67 R199 S203 E206 K237 S258 Y259 K262

External links

PDB	RCSB:6cta, PDBe:6cta, PDBj:6cta
PDBsum	6cta
PubMed	30007416
UniProt	Q8N884\|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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