Structure of PDB 6ct9 Chain A

Receptor sequence
>6ct9A (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVNGVVDHLLRRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKENPLSQ
FLEGEILSASKMLSKFRKIIKEEINDIDVIMKGGSPAVTLLISEKISVDI
TLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKGFQEE
TWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKER
FKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQ
CLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB6ct9 Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S180 A183 N210 Y214 Y215 K384 S20 A23 N50 Y54 Y55 K211
BS02 dna A K173 L174 S175 R176 K198 H217 K407 K13 L14 S15 R16 K38 H57 K234
BS03 ZN A H390 C396 C397 C404 H217 C223 C224 C231
External links
PDB RCSB:6ct9, PDBe:6ct9, PDBj:6ct9
PDBsum6ct9
PubMed30007416
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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