Structure of PDB 6ct2 Chain A

Receptor sequence
>6ct2A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
VKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRF
HLGQCQWRQPPGKEIYRKSNISVHEVDGKDHKIYCQNLCLLAKLFLDHKT
LYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVSCIMILPPYQR
RGYGRFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLENLRD
FRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEH
LKSAQYKKPPITVDSVCLKWAPPK
3D structure
PDB6ct2 Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
ChainA
Resolution2.128 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FCV A L601 M648 I649 Q654 R655 R656 G657 G659 R660 S684 L686 S690 L96 M143 I144 Q149 R150 R151 G152 G154 R155 S179 L181 S185
BS02 ZN A C540 C543 H556 C560 C35 C38 H51 C55
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6ct2, PDBe:6ct2, PDBj:6ct2
PDBsum6ct2
PubMed30069049
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

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