Structure of PDB 6crg Chain A

Receptor sequence
>6crgA (length=477) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSDFTLSVRRNGAVTHIKIQN
TGDYYDLYGGEKFATLAKLVQYYMEHVIELKYPLNCADPTSERWFHGHLS
GKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGSNDGKSKVTHVMIR
CQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINA
AEIESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNI
LPFDHTRVVLHDGPVSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQE
NSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTL
RELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQES
IMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVR
SQRSGMVQTEAQYRFIYMAVQHYIETL
3D structure
PDB6crg Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.
ChainA
Resolution2.75 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5OD A R111 F113 T219 E250 T253 L254 Q257 P491 K492 Q495 R93 F95 T196 E218 T221 L222 Q225 P443 K444 Q447 BindingDB: IC50=70.0nM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6crg, PDBe:6crg, PDBj:6crg
PDBsum6crg
PubMed30375388
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

[Back to BioLiP]