Structure of PDB 6cr0 Chain A

Receptor sequence
>6cr0A (length=430) Species: 879274 (Shinella sp. HZN7) [Search protein sequence]
IYDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGGRTHVVNFLGRPV
EIGGAGVHWCQPHVFAEMQRYGFGFKEAPLADLDKAYMVFADGQKIDVPP
ATFDEEYTTAFEKFCSRSRELFPRPYSPLDNHEVSNLDGVSARDHLESLG
LNELQLASMNAELTLYGGAPTTELSYPSFVKFHALASWDTITFTDSEKRY
HVQGGTNALCQAIFDDCRADSEFGVPVEAVAQTDNGVTVTLADKRVFRAL
TCVLTLPTKVYADVRFEPPLPPEKRAFIEHAEMADGAELYVHVRQNLGNT
FTFCDDPNPFNAVQTYAYDDELGTILKITIGRQSLINLENFDAIAAEIRK
IHGDVEVLEALPYNWAMDEYARTSYPAMRKGWFSRYKDMAKPENRLFFAG
SATADGWHEYIDGAIESGIRVGREIRHFMK
3D structure
PDB6cr0 Improving the kinetic parameters of nicotine oxidizing enzymes by homologous structure comparison and rational design
ChainA
Resolution1.548 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.3.5: (S)-6-hydroxynicotine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D86 D88 D82 D84
BS02 FAD A G12 G14 S16 E35 A36D R37 G42 R43 T44 G58 G60 P230 V231 L260 W369 Y374 S378 Y379 G404 S405 Y414 I415 A418 G8 G10 S12 E31 A32 R33 G38 R39 T40 G54 G56 P226 V227 L256 W365 Y370 S374 Y375 G400 S401 Y410 I411 A414
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0018531 (S)-6-hydroxynicotine oxidase activity
Biological Process
GO:0009820 alkaloid metabolic process
GO:0019608 nicotine catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6cr0, PDBe:6cr0, PDBj:6cr0
PDBsum6cr0
PubMed
UniProtA0A075BSX9|HLNO_SHIS7 (S)-6-hydroxynicotine oxidase (Gene Name=nctB)

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