Structure of PDB 6cqf Chain A

Receptor sequence
>6cqfA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
PDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD
VSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQV
TGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLAD
FGISAQIRLAFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAEL
QPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKK
RPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
3D structure
PDB6cqf Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.
ChainA
Resolution2.246 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 T175
Catalytic site (residue number reindexed from 1) D132 K134 A136 N137 D150 T164
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F97 A L23 G24 A44 M91 F93 C94 G95 G97 D101 L144 L18 G19 A39 M86 F88 C89 G90 G92 D96 L139 MOAD: ic50=0.0045uM
PDBbind-CN: -logKd/Ki=8.35,IC50=4.5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6cqf, PDBe:6cqf, PDBj:6cqf
PDBsum6cqf
PubMed30503777
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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