Structure of PDB 6cqd Chain A

Receptor sequence
>6cqdA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
DVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVDDD
VSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQV
TGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLAD
FGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITA
IELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTL
TKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNG
3D structure
PDB6cqd Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.
ChainA
Resolution2.12 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D132 K134 A136 N137 D150 A159 T170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A L23 G26 V31 A44 K46 M91 C94 D101 A141 L144 D155 L22 G25 V30 A43 K45 M86 C89 D96 A136 L139 D150
BS02 MG A N142 D155 N137 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6cqd, PDBe:6cqd, PDBj:6cqd
PDBsum6cqd
PubMed30503777
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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