Structure of PDB 6cq2 Chain A

Receptor sequence
>6cq2A (length=688) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKS
QPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDRE
GEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQE
TRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRS
AAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRK
GDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQE
ASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQL
YGDEYVAPAPRQYTRKVKNAQEHEAIRPAGETFATPDAVRRELDGPNIDD
FRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPG
FLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPAR
YTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAV
TGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVP
DSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYL
ERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFAT
3D structure
PDB6cq2 Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site.
ChainA
Resolution3.004 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E24 D111 D113 E115 Y342 R344 H389
Catalytic site (residue number reindexed from 1) E9 D96 D98 E100 Y327 R329 H373
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6cq2, PDBe:6cq2, PDBj:6cq2
PDBsum6cq2
PubMed29905859
UniProtP9WG49|TOP1_MYCTU DNA topoisomerase 1 (Gene Name=topA)

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