Structure of PDB 6coj Chain A

Receptor sequence
>6cojA (length=295) Species: 101510 (Rhodococcus jostii RHA1) [Search protein sequence]
VSKRDKRISLDDAVGELRSGMTIGIGGWGSRRKPMALVRALLRSDVTDLT
VVTYGGPDLGLLCSAGKVTKAYYGFVSLDSAPFYDPWFAKARTAGEIAVR
EMDAGMVKCGLEAAAARLPFLPIRAGLGSDVRRFWGDELRTVTSPYPDAS
GKSETLIAMPALNLDAALVHLNLGDKHGNAAYTGVDPYFDDLYCAAAEKR
FVSVERVVETEELVKTVPLQNLILNRMMVDGVVEAPNGAHFTLAGDSYGR
DEKFQRHYAESAKTPQAWQQFVATYLSGSEDDYQAAVKKFAEEQA
3D structure
PDB6coj IpdAB, a virulence factor inMycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F8G A W29 Y85 W28 Y84 PDBbind-CN: -logKd/Ki=6.40,Kd=0.4uM
Gene Ontology
Molecular Function
GO:0008410 CoA-transferase activity
GO:0016829 lyase activity
Biological Process
GO:0006707 cholesterol catabolic process
GO:0008203 cholesterol metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6coj, PDBe:6coj, PDBj:6coj
PDBsum6coj
PubMed29581275
UniProtQ0S7P9|IPDA_RHOJR Cholesterol ring-cleaving hydrolase IpdA subunit (Gene Name=ipdA)

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