Structure of PDB 6cn2 Chain A

Receptor sequence
>6cn2A (length=300) Species: 7955 (Danio rerio) [Search protein sequence]
TSSALKGAIQLGITHSVGSLSQKPERDVLMQDFEVVESIFFPSQGSSSTP
GHHHGDFKFKTYAPIAFRYFREMFGIRPDDYLYSLCNEPLIELSSLFYVS
SDDEFIIKTVQHKEAEFLQTLLPGYFMNLNQNMRTLLPKFYGLYCVQADG
KNIRIVVMNNLLPRAVPMHLKFNLKGSTYKRRASPKERSKGVPTYKDLDF
MQDMPEGILLENDHYTALSRTMQRDCRVLQSFKIMDYSLLVGIHILHMGG
IPAFNSKGERLLVFIGIIDILQSYRTVSVHRPSFYADRFQKFMCSTVFRK
3D structure
PDB6cn2 Structural insights into lethal contractural syndrome type 3 (LCCS3) caused by a missense mutation of PIP5K gamma.
ChainA
Resolution3.102 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.68: 1-phosphatidylinositol-4-phosphate 5-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A F160 I169 K171 L224 N236 L303 I377 D378 F97 I106 K108 L161 N173 L240 I268 D269
BS02 CA A K238 D378 K175 D269
Gene Ontology
Molecular Function
GO:0052742 phosphatidylinositol kinase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6cn2, PDBe:6cn2, PDBj:6cn2
PDBsum6cn2
PubMed29959184
UniProtQ503I3

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