Structure of PDB 6cmz Chain A

Receptor sequence

>6cmzA (length=462) Species: 216591 (Burkholderia cenocepacia J2315)

KNEHTTLLVIGGGPGGYVAAIRAGQLGIPTVLVERDRLGGTCLNIGCIPS
KALIHVADAFEQACGHAGEGALGIRVRAPEIDIAKSVAWKDGIVDRLTRG
VGALLKKSGVRVLHGEARVIDGKTVEVVSAGHAVRIGCEHLLLATGSEPV
ELPSMPFGGHVVSSTDALSPATLPKRLVVVGAGYIGLELGIVYRKLGVDV
SVVEAAERVLPAYDAELVRPVADSLARLGVRLWLGHKVLGLDKHGAVRVQ
AADGAEQTLPADRVLVAVGRRPRVDGFGLETLMLDRNGRALRIDDTCRTS
MRNVWAIGDVAGEPMLAHRAMAQGEMVAELIAGRRRQFMPAAIPAVCFTD
PEIVTAGWSPDDAHAAGVDCLSASFPFAANGRAMTLQATDGFVRVVARRD
NHLIVGWQAVGRGVSELAAAFSQSLEMGARLEDIGGTIHAHPTLGEALQE
AALRALGHALHV

3D structure

• PDB: 6cmz 2.3 Angstrom Resolution Crystal Structure of Dihydrolipoamide Dehydrogenase from Burkholderia cenocepacia in Complex with FAD and NAD.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C43 C48 S51 Y185 E189 H442 E447
• Catalytic site (residue number reindexed from 1): C42 C47 S50 Y184 E188 H441 E446
• Enzyme Commision number: 1.8.1.4: dihydrolipoyl dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G12 G14 P15 E35 R36 G41 T42 C43 G47 C48 K52 E117 A118 T146 G147 Y185 I186 R271 R274 F278 G309 D310 M316 L317 A318 H319	G11 G13 P14 E34 R35 G40 T41 C42 G46 C47 K51 E116 A117 T145 G146 Y184 I185 R270 R273 F277 G308 D309 M315 L316 A317 H318
BS02	FAD	A	V181 G182 E205 V269 R290	V180 G181 E204 V268 R289
BS03	FMN	A	L153 P154	L152 P153

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004148 dihydrolipoyl dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
• GO:0050660 flavin adenine dinucleotide binding

External links

• PDB: RCSB:6cmz, PDBe:6cmz, PDBj:6cmz
• PDBsum: 6cmz
• UniProt: B4EEF2