Structure of PDB 6cms Chain A

Receptor sequence
>6cmsA (length=497) Species: 9606 (Homo sapiens) [Search protein sequence]
TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSPGDFTLSVRRNGAVTHI
KIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNC
ADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTG
DDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVE
TLGTVLQLKQPLNTTRINAAEIESRVRELSKKQGFWEEFETLQQQECKLL
YSRKEGQRQENKNKNRYKNILPFDHTRVVLHSDYINANIIMPEKKSYIAT
QGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEY
GVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPS
DPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQR
3D structure
PDB6cms Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2.
ChainA
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5OD A R111 F113 T218 T219 T253 L254 Q257 P491 K492 Q495 R107 F109 T214 T215 T241 L242 Q245 P461 K462 Q465 PDBbind-CN: -logKd/Ki=5.82,Kd=1.5uM
BindingDB: IC50=70.0nM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6cms, PDBe:6cms, PDBj:6cms
PDBsum6cms
PubMed30375376
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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