Structure of PDB 6cmj Chain A

Receptor sequence
>6cmjA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
QLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQ
PRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV
MEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH
IKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWA
MGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITR
MLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTL
3D structure
PDB6cmj An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D312 K314 S316 N317 D330 T350
Catalytic site (residue number reindexed from 1) D137 K139 S141 N142 D155 T175
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6J A I171 G174 V179 A192 K194 F267 L269 V270 G273 P274 L319 D330 I11 G14 V19 A32 K34 F92 L94 V95 G98 P99 L144 D155 MOAD: ic50=5nM
PDBbind-CN: -logKd/Ki=8.30,IC50=5nM
BindingDB: IC50=25nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6cmj, PDBe:6cmj, PDBj:6cmj
PDBsum6cmj
PubMed29653895
UniProtQ96RR4|KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 (Gene Name=CAMKK2)

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