Structure of PDB 6clv Chain A

Receptor sequence
>6clvA (length=256) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
TKTKIMGILNVTPDSLSNVESAVTRVKAMMDEGADIIDVGGVSTRPGHEM
ITVEEELNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDIINDQWA
GLYDHRMFQVVAKYDAEIVLMHNGNGNRDEPVVEEMLTSLLAQAHQAKIA
GIPSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTK
KMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLK
ENENAR
3D structure
PDB6clv The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6MB A R52 D84 N103 M128 D167 F172 A199 K203 R204 R239 R45 D77 N96 M121 D160 F165 A192 K196 R197 R232 PDBbind-CN: -logKd/Ki=4.88,Kd=13.3uM
Gene Ontology
Molecular Function
GO:0004156 dihydropteroate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6clv, PDBe:6clv, PDBj:6clv
PDBsum6clv
PubMed30065703
UniProtO05701|DHPS_STAAU Dihydropteroate synthase (Gene Name=folP)

[Back to BioLiP]