Structure of PDB 6cks Chain A

Receptor sequence
>6cksA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTWKHQFAWPFQQPVDAVKLN
LPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPG
DDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6cks Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.
ChainA
Resolution1.72 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F5Y A W81 P82 Q85 V87 D88 L92 N140 I146 W38 P39 Q42 V44 D45 L49 N97 I103 MOAD: ic50=0.015uM
PDBbind-CN: -logKd/Ki=7.82,Kd=0.015uM
BindingDB: IC50=15nM
External links
PDB RCSB:6cks, PDBe:6cks, PDBj:6cks
PDBsum6cks
PubMed29657099
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]