Structure of PDB 6ckr Chain A

Receptor sequence
>6ckrA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB6ckr Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F5V A W81 P82 Q85 V87 D88 K91 L92 N140 I146 W39 P40 Q43 V45 D46 K49 L50 N98 I104 MOAD: ic50=0.05uM
PDBbind-CN: -logKd/Ki=7.30,Kd=0.05uM
BindingDB: IC50=50nM
External links
PDB RCSB:6ckr, PDBe:6ckr, PDBj:6ckr
PDBsum6ckr
PubMed29657099
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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