Structure of PDB 6ckl Chain A

Receptor sequence
>6cklA (length=225) Species: 487 (Neisseria meningitidis) [Search protein sequence]
MEKQNIAVILARQNSKGLPLKNLRKMNGISLLGHTINAAISSKCFDRIIV
STDGGLIAEEAKNFGVEVVLRPAELASDTASSISGVIHALETIGSNSGTV
TLLQPTSPLRTGAHIREAFSLFDEKIKGSVVSACPMEHHPLKTLLQINNG
EYAPMRHLSDLEQPRQQLPQAFRPNGAIYINDTASLIANNCFFIAPTKLY
IMSHQDSIDIDTELDLQQAENILNH
3D structure
PDB6ckl Catalytic Cycle ofNeisseria meningitidisCMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography.
ChainA
Resolution2.684 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.43: N-acylneuraminate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P A L10 A11 R12 N22 R71 A80 Q104 T106 L10 A11 R12 N22 R71 A80 Q104 T106
BS02 DAN A K142 L161 E162 P164 R165 K142 L161 E162 P164 R165 PDBbind-CN: -logKd/Ki=3.89,IC50=130uM
BS03 DAN A S82 Q104 Y179 S82 Q104 Y179 PDBbind-CN: -logKd/Ki=3.89,IC50=130uM
Gene Ontology
Molecular Function
GO:0008781 N-acylneuraminate cytidylyltransferase activity
GO:0016779 nucleotidyltransferase activity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:6ckl, PDBe:6ckl, PDBj:6ckl
PDBsum6ckl
PubMed31583886
UniProtP0A0Z8|NEUA_NEIME N-acylneuraminate cytidylyltransferase (Gene Name=neuA)

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