Structure of PDB 6cjp Chain A

Receptor sequence
>6cjpA (length=214) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
LYFQGETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQ
ALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAK
SGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVW
ESNGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEF
VAYPIQLVVTKEVE
3D structure
PDB6cjp Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F5S A L37 N40 D43 A44 K47 D82 M87 N95 G126 F127 L130 T174 L176 L36 N39 D42 A43 K46 D81 M86 N94 G125 F126 L129 T171 L173 PDBbind-CN: -logKd/Ki=8.11,Ki=7.7nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6cjp, PDBe:6cjp, PDBj:6cjp
PDBsum6cjp
PubMed30679438
UniProtP46598|HSP90_CANAL Heat shock protein 90 homolog (Gene Name=HSP90)

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