Structure of PDB 6cje Chain A

Receptor sequence
>6cjeA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
STDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSH
IHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVS
PVKICDFGPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSG
YPPFVGRCCGACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLL
VRDAKQRLSAAQVLQHPWVQGC
3D structure
PDB6cje Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
ChainA
Resolution3.36 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D205 K207 N210 D226 S253
Catalytic site (residue number reindexed from 1) D135 K137 N140 D156 S162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F4A A K113 M162 L212 C225 D226 K43 M92 L142 C155 D156 PDBbind-CN: -logKd/Ki=7.22,IC50=0.06uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6cje, PDBe:6cje, PDBj:6cje
PDBsum6cje
PubMed29526098
UniProtQ9HBH9|MKNK2_HUMAN MAP kinase-interacting serine/threonine-protein kinase 2 (Gene Name=MKNK2)

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