Structure of PDB 6cj1 Chain A

Receptor sequence
>6cj1A (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB6cj1 Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F2S A W81 P82 Q85 L92 L94 Y139 N140 I146 W40 P41 Q44 L51 L53 Y98 N99 I105 PDBbind-CN: -logKd/Ki=5.27,IC50=5.42uM
BS02 FND A W81 P82 Q85 L92 L94 Y139 N140 I146 W40 P41 Q44 L51 L53 Y98 N99 I105 MOAD: ic50=6.31uM
External links
PDB RCSB:6cj1, PDBe:6cj1, PDBj:6cj1
PDBsum6cj1
PubMed30102854
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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