Structure of PDB 6ciy Chain A

Receptor sequence
>6ciyA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB6ciy Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
ChainA
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F3J A W81 P82 Q85 L92 L94 Y139 N140 W40 P41 Q44 L51 L53 Y98 N99 MOAD: ic50=0.41uM
PDBbind-CN: -logKd/Ki=6.70,IC50=0.201uM
External links
PDB RCSB:6ciy, PDBe:6ciy, PDBj:6ciy
PDBsum6ciy
PubMed30102854
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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