Structure of PDB 6cgg Chain A

Receptor sequence
>6cggA (length=296) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
NATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFST
NKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLT
PEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYI
LLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLD
GNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNID
IEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
3D structure
PDB6cgg Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A S214 I224 K226 Y237 Y274 E276 I277 F281 H379 I392 D393 S33 I43 K45 Y54 Y91 E93 I94 F98 H196 I209 D210
BS02 MG A H379 D393 H196 D210
External links
PDB RCSB:6cgg, PDBe:6cgg, PDBj:6cgg
PDBsum6cgg
PubMed29661878
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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