Structure of PDB 6cgd Chain A

Receptor sequence
>6cgdA (length=298) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
NATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFST
NKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTF
LTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEE
YILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLL
LDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGN
IDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
3D structure
PDB6cgd Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A I224 K226 Y237 Y274 E276 I277 F281 H379 I392 D393 I43 K45 Y56 Y93 E95 I96 F100 H198 I211 D212
BS02 AKN A Y212 D374 D396 Y408 E411 Y448 E451 Y31 D193 D215 Y227 E230 Y267 E270
BS03 MG A H379 D393 H198 D212
External links
PDB RCSB:6cgd, PDBe:6cgd, PDBj:6cgd
PDBsum6cgd
PubMed29661878
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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