Structure of PDB 6cff Chain A

Receptor sequence
>6cffA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
NVAHGLAWSYYIGYLRLILPELQARIRTYNQAVSQRLYILLPLDCGVPDN
LSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEY
ATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRL
IAYQEPSLSQEVLRHLRQ
3D structure
PDB6cff STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
ChainA
Resolution2.396 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2BA A S162 Y163 G166 Y167 R238 Y240 P264 S9 Y10 G13 Y14 R77 Y79 P103 BindingDB: EC50=200nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6cff, PDBe:6cff, PDBj:6cff
PDBsum6cff
PubMed31230712
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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