Structure of PDB 6cee Chain A

Receptor sequence
>6ceeA (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
SPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYI
NGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKF
3D structure
PDB6cee Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1145 C1148 H1164 H1170 C38 C41 H57 H63
BS02 ZN A C1133 C1136 C1153 H1160 C26 C29 C46 H53
BS03 ZN A C1113 H1115 C1183 C1186 C6 H8 C76 C79
BS04 EYM A W1143 G1154 R1155 W1182 Y1184 Y1189 W36 G47 R48 W75 Y77 Y82 MOAD: ic50=65uM
PDBbind-CN: -logKd/Ki=4.19,IC50=65uM
BindingDB: IC50=65000nM
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:6cee, PDBe:6cee, PDBj:6cee
PDBsum6cee
PubMed29741882
UniProtQ9UBN7|HDAC6_HUMAN Histone deacetylase 6 (Gene Name=HDAC6)

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