Structure of PDB 6cd4 Chain A

Receptor sequence
>6cd4A (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
TNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPT
3D structure
PDB6cd4 Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
ChainA
Resolution1.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EX1 A W81 P82 L92 L94 Y139 I146 W39 P40 L50 L52 Y97 I104 MOAD: ic50=5.14uM
PDBbind-CN: -logKd/Ki=5.34,IC50=4.59uM
External links
PDB RCSB:6cd4, PDBe:6cd4, PDBj:6cd4
PDBsum6cd4
PubMed30102854
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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