Structure of PDB 6cbz Chain A

Receptor sequence
>6cbzA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNK
GMEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB6cbz Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 Q375 V376 D538 E542 I50 K54 L64 Q67 V68 D218 E222
BS02 EST A E353 F404 H524 L525 E45 F96 H204 L205 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:6cbz, PDBe:6cbz, PDBj:6cbz
PDBsum6cbz
PubMed29739819
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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