Structure of PDB 6cbk Chain A

Receptor sequence
>6cbkA (length=409) Species: 1906 (Streptomyces fradiae) [Search protein sequence]
SLLAEFPTCPRDEKDRPRVFTAASGAWLTDESGFRWIDFDNARGSILLGH
GDPVVAEAVARAATGADGTATGWSRRVDAVLERLHALCGGEVVGLFRSGT
AAVRAAVLAVREATGRPLLLSAGYHGYDPMWYPSEAPLEPNADGVVDFFF
DLGLLRELLRAPERVAAVVVSPDHMHLSPGWYRELRRLCSAAGVVLVADE
VKVGLRYAPGLSTAELLAPDVWVVAKGMANGHAVSAVGGSRRLLKPLKEV
SFTSFFEPTILAAADAALARVATGEPQRAVREAGDRFLRHARKALDDASL
PVEIAGDGTFFQFVPATEELEEALYGAANAEGLLFYAGDNQGVSAAFDEA
VLGEAERRFARVCERLAPYAGGEPVGDAARYRVAWNVMDGLRQAPRDREE
TTGLLARLL
3D structure
PDB6cbk The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y129 D204 K231
Catalytic site (residue number reindexed from 1) Y124 D199 K226
Enzyme Commision number 2.6.1.93: neamine transaminase.
2.6.1.95: neomycin C transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PMP A G104 T105 Y129 H130 G131 S176 D204 V206 K231 G99 T100 Y124 H125 G126 S171 D199 V201 K226
BS02 PMP A F257 T258 F252 T253
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:1901158 neomycin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6cbk, PDBe:6cbk, PDBj:6cbk
PDBsum6cbk
PubMed29516565
UniProtQ53U08|NEON_STRFR Neamine transaminase NeoN (Gene Name=neoN)

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