Structure of PDB 6cax Chain A

Receptor sequence
>6caxA (length=300) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
SMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVE
IPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASE
VPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPF
DGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEY
LRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLL
GNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP
3D structure
PDB6cax Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT805
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EUY A M62 E77 T190 F191 G192 M194 I197 G209 V216 H237 D241 H264 M63 E78 T191 F192 G193 M195 I198 G210 V217 H238 D242 H265
BS02 EUY A A84 F152 F176 S177 S178 T179 S180 F181 I243 S252 L253 A85 F153 F177 S178 S179 T180 S181 F182 I244 S253 L254
BS03 ZN A H78 H237 D241 H79 H238 D242
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0103117 UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0009245 lipid A biosynthetic process
GO:0019637 organophosphate metabolic process
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6cax, PDBe:6cax, PDBj:6cax
PDBsum6cax
PubMed
UniProtB7UZI4|LPXC_PSEA8 UDP-3-O-acyl-N-acetylglucosamine deacetylase (Gene Name=lpxC)

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