Structure of PDB 6cav Chain A

Receptor sequence
>6cavA (length=288) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
ATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFYAK
EKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYST
MSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETI
YNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLT
GIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKE
YQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTY
3D structure
PDB6cav Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A S214 I224 K226 Y237 Y274 E276 I277 F281 H379 I392 D393 S32 I42 K44 Y48 Y85 E87 I88 F92 H190 I203 D204
BS02 MG A H379 D393 H190 D204
BS03 84D A D374 S376 D396 Y408 E411 E415 E416 Y448 E451 D185 S187 D207 Y219 E222 E226 E227 Y259 E262
External links
PDB RCSB:6cav, PDBe:6cav, PDBj:6cav
PDBsum6cav
PubMed29661878
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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