Structure of PDB 6c9c Chain A

Receptor sequence

>6c9cA (length=291) Species: 208963 (Pseudomonas aeruginosa UCBPP-PA14) [Search protein sequence]

SMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVE
IPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASE
VPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPF
DGFKVSFEIDFDHPVFRQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRS
QNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNS
LIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAP

3D structure

PDB

6c9c Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT803

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	EU1	A	M62 E77 H78 T190 F191 G192 M194 I197 R201 G209 V216 K238 D241 H264	M63 E78 H79 T188 F189 G190 M192 I195 R199 G207 V214 K236 D239 H262
BS02	F64	A	L18 M62 E77 T190 F191 G192 M194 I197 R201 G209 V216 H237 D241 H264	L19 M63 E78 T188 F189 G190 M192 I195 R199 G207 V214 H235 D239 H262
BS03	ZN	A	H78 H237 D241	H79 H235 D239

Gene Ontology

	Molecular Function
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0103117	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity

	Biological Process
GO:0006796	phosphate-containing compound metabolic process
GO:0009245	lipid A biosynthetic process
GO:0019637	organophosphate metabolic process
GO:1901135	carbohydrate derivative metabolic process

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6c9c, PDBe:6c9c, PDBj:6c9c
PDBsum	6c9c
PubMed
UniProt	Q02H34\|LPXC_PSEAB UDP-3-O-acyl-N-acetylglucosamine deacetylase (Gene Name=lpxC)

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