Structure of PDB 6c8s Chain A

Receptor sequence
>6c8sA (length=354) Species: 4058 (Catharanthus roseus) [Search protein sequence]
PMKGGDDSHSYSQNSCYQKGVIDAAKAVIVEAVNEKLDLENNPIFDPIKP
FRIADFGCSTGPNTFHAMQNIVESVETKYKSLQKTPEFHVFFNDHVNNDF
NVLFRSLPPNREFFAAGVPGSFYTRVFPKNSIHFAHCSYALHWLSKVPKE
IQDKNSLAYNKGRIHYTGTEKHVVKAYFGQFQRDFEGFLKARAQEIVVGG
LMVIQIPGLPSGEVLFSRTGAGLLHFLLGTSLMELVNKGIINEESVDSFN
LPQYHPSVEDLEMVIEMNDCFTIERVGTLPHPMKNLPFDVQRTSLQVRAI
MECILTEHFGENILDPLFEIYTKNLQENFHVFDKEIRKDADLYLVLKRKG
NLEH
3D structure
PDB6c8s Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.50: loganate O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A P21 M22 Y31 G77 S79 N83 D114 H115 S141 F142 Y143 S158 Y159 P1 M2 Y11 G57 S59 N63 D94 H95 S121 F122 Y123 S138 Y139
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0030749 loganate O-methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0032259 methylation
GO:0035834 indole alkaloid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6c8s, PDBe:6c8s, PDBj:6c8s
PDBsum6c8s
PubMed29399933
UniProtB2KPR3|LAMT_CATRO Loganic acid O-methyltransferase (Gene Name=LAMT)

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