Structure of PDB 6c7y Chain A

Receptor sequence
>6c7yA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
AHFEKRFLKRIRDLGEGHFGKVELCRYGDNTGEQVAVKSLKPHIADLKKE
IEILRNLYHENIVKYKGICTEGIKLIMEFLPSGSLKEYLPKNKNKINLKQ
QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIE
TDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCD
SDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMR
KCWEFQPSNRTSFQNLIEGFEALL
3D structure
PDB6c7y The molecular basis of JAK/STAT inhibition by SOCS1.
ChainA
Resolution2.499 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1003 R1007 N1008 D1021
Catalytic site (residue number reindexed from 1) D124 R128 N129 D142
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ADP A G882 G884 F886 G887 V889 A906 K908 L959 S963 R1007 L1010 D1021 G15 G17 F19 G20 V22 A36 K38 L80 S84 R128 L131 D142
BS02 MG A N1008 D1021 N129 D142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function

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Biological Process
External links
PDB RCSB:6c7y, PDBe:6c7y, PDBj:6c7y
PDBsum6c7y
PubMed29674694
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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