Structure of PDB 6c6r Chain A

Receptor sequence
>6c6rA (length=451) Species: 9606 (Homo sapiens) [Search protein sequence]
NDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGG
YHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSG
RAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETG
DIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANH
AELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDH
LKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGM
TVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQ
ALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIG
HFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKY
M
3D structure
PDB6c6r Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.17: squalene monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G130 G132 V133 I152 E153 R154 R161 V163 G164 F166 V249 V250 D285 G286 D408 P415 G418 G420 M421 G9 G11 V12 I31 E32 R33 R40 V42 G43 F45 V128 V129 D164 G165 D287 P294 G297 G299 M300
Gene Ontology
Molecular Function
GO:0004506 squalene monooxygenase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0016126 sterol biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c6r, PDBe:6c6r, PDBj:6c6r
PDBsum6c6r
PubMed30626872
UniProtQ14534|ERG1_HUMAN Squalene monooxygenase (Gene Name=SQLE)

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