Structure of PDB 6c5q Chain A

Receptor sequence
>6c5qA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHGSHMESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVI
YDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEY
AKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMT
REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPG
LLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEH
VQLLQVIKKTETDMSLHPLLQEIYKDLY
3D structure
PDB6c5q PPAR gamma in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.
ChainA
Resolution2.404 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EKS A G284 C285 F287 R288 M329 L330 L333 I341 S342 Y473 G85 C86 F88 R89 M130 L131 L134 I142 S143 Y274 MOAD: ic50=220nM
PDBbind-CN: -logKd/Ki=6.66,IC50=220nM
BindingDB: IC50=321nM
BS02 EKS A G258 I262 F264 K265 H266 R280 Q283 L465 Y473 G59 I63 F65 K66 H67 R81 Q84 L266 Y274 MOAD: ic50=220nM
PDBbind-CN: -logKd/Ki=6.66,IC50=220nM
BindingDB: IC50=321nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c5q, PDBe:6c5q, PDBj:6c5q
PDBsum6c5q
PubMed30123887
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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