Structure of PDB 6c4d Chain A

Receptor sequence
>6c4dA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
NVIKMKSSDFLEGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEA
KMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSV
KGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKM
WSKLNNEEHNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEP
YENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPT
FPGIEEKFRPFYLSQLE
3D structure
PDB6c4d Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
ChainA
Resolution2.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D124 K126 E128 N129 D142 T162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EJP A K45 L70 V76 L78 L90 M92 V134 A155 D156 L157 L159 S161 F162 K31 L56 V62 L64 L76 M78 V120 A141 D142 L143 L145 S147 F148 PDBbind-CN: -logKd/Ki=9.04,Ki=0.912nM
BindingDB: IC50=1.3nM,Ki=0.912011nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6c4d, PDBe:6c4d, PDBj:6c4d
PDBsum6c4d
PubMed29485864
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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