Structure of PDB 6c4a Chain A

Receptor sequence
>6c4aA (length=428) Species: 652616 (Mycobacterium tuberculosis str. Erdman = ATCC 35801) [Search protein sequence]
HMSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA
RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA
NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP
IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVL
IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI
TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE
AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA
GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA
GYFDRIATTVDPNSSTTALTGSTEEGQF
3D structure
PDB6c4a The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y89 D108 D153 E155 H180 E182 C191 H193 R228 E285 Q308 S315 S317
Catalytic site (residue number reindexed from 1) Y90 D109 D154 E156 H181 E183 C192 H194 R229 E286 Q309 S316 S318
Enzyme Commision number 4.1.3.1: isocitrate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PYR A Y89 S91 G92 W93 D153 X191 R228 W283 T347 Y90 S92 G93 W94 D154 X192 R229 W284 T348
BS02 MG A A276 A279 Q308 A277 A280 Q309
BS03 3NP A Y356 S357 R379 Y357 S358 R380
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity
GO:0016829 lyase activity
GO:0035375 zymogen binding
GO:0046421 methylisocitrate lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0052572 response to host immune response
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c4a, PDBe:6c4a, PDBj:6c4a
PDBsum6c4a
PubMed29782144
UniProtP9WKK7|ACEA_MYCTU Isocitrate lyase (Gene Name=icl)

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