Structure of PDB 6c3z Chain A

Receptor sequence

>6c3zA (length=462) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

LRCRLPGGVITTKQWQAIDKFAGENTIYGSIRLTNRQTFQFHGILKKNVK
PVHQMLHSVGLDALATNDMNRNVLCTSNPYESQLHAEAYEWAKKISEHLL
PTYLPRKFKTTVVIPPQNDIDLHANDMNFVAIAENGKLVGFNLLVGGGLS
IEHGNKKTYARTASEFGYLPLEHTLAVAEAVVTTQRDWGNRTDRKNAKTK
YTLERVGVETFKAEVERRAGIKFEPIRPYEFTGRGDRIGWVKGIDDNWHL
TLFIENGRILDYPARPLKTGLLEIAKIHKGDFRITANQNLIIAGVPESEK
AKIEKIAKESGLMNAVTPQRENSMACVSFPTCPLAMAEAERFLPSFIDNI
DNLMAKHGVSDEHIVMRVAGCPNGCGRAMLAEVGLVGKAPGRYNLHLGGN
RIGTRIPRMYKENITEPEILASLDELIGRWAKEREAGEGFGDFTVRAGII
RPVLDPARDLWD

3D structure

PDB

6c3z The role of extended Fe4S4cluster ligands in mediating sulfite reductase hemoprotein activity.

Chain

Resolution

1.681 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	A394
Catalytic site (residue number reindexed from 1)	A286
Enzyme Commision number	1.8.1.2: assimilatory sulfite reductase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	A	C434 S436 C440 A443 G478 C479 C483	C326 S328 C332 A335 G370 C371 C375
BS02	SRM	A	R83 R113 T115 N116 R117 H123 R214 K215 K217 G256 S258 Q396 C434 V435 T439 C440 P441 L442 N481 C483 R485	R2 R32 T34 N35 R36 H42 R106 K107 K109 G148 S150 Q288 C326 V327 T331 C332 P333 L334 N373 C375 R377

Gene Ontology

	Molecular Function
GO:0004783	sulfite reductase (NADPH) activity
GO:0016002	sulfite reductase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0050311	sulfite reductase (ferredoxin) activity
GO:0050661	NADP binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0000103	sulfate assimilation
GO:0008652	amino acid biosynthetic process
GO:0019344	cysteine biosynthetic process
GO:0070814	hydrogen sulfide biosynthetic process

	Cellular Component
GO:0009337	sulfite reductase complex (NADPH)

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6c3z, PDBe:6c3z, PDBj:6c3z
PDBsum	6c3z
PubMed	29852252
UniProt	P17846\|CYSI_ECOLI Sulfite reductase [NADPH] hemoprotein beta-component (Gene Name=cysI)

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