Structure of PDB 6c3m Chain A

Receptor sequence

>6c3mA (length=465) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

MLLRCRLPGGVITTKQWQAIDKFAGENTIYGSIRLTNRQTFQFHGILKKN
VKPVHQMLHSVGLDALATANDMNRNVLCTSNPYESQLHAEAYEWAKKISE
HLLPTYLPRKFKTTVVIPPQNDIDLHANDMNFVAIAENGKLVGFNLLVGG
GLSIEHGNKKTYARTASEFGYLPLEHTLAVAEAVVTTQRDWGNRTDRKNA
KTKYTLERVGVETFKAEVERRAGIKFEPIRPYEFTGRGDRIGWVKGIDDN
WHLTLFIENGRILDYPARPLKTGLLEIAKIHKGDFRITANQNLIIAGVPE
SEKAKIEKIAKESGLMNAVTPQRENSMACVSFPTCPLAMAEAERFLPSFI
DNIDNLMAKHGVSDEHIVMRVTGCPNGCGRAMLAEVGLVGKAPGRYNLHL
GGNRIGTRIPRMYKENITEPEILASLDELIGRWAKEREAGEGFGDFTVRA
GIIRPVLDPARDLWD

3D structure

PDB

6c3m The role of extended Fe4S4cluster ligands in mediating sulfite reductase hemoprotein activity.

Chain

Resolution

1.5 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	A394
Catalytic site (residue number reindexed from 1)	A289
Enzyme Commision number	1.8.1.2: assimilatory sulfite reductase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	A	C434 S436 C440 A443 G478 C479 N481 C483	C329 S331 C335 A338 G373 C374 N376 C378
BS02	SRM	A	R83 R113 T115 N116 R117 Q121 H123 R214 K215 K217 G256 S258 Q396 C434 V435 T439 C440 P441 L442 N481 C483 R485	R4 R34 T36 N37 R38 Q42 H44 R109 K110 K112 G151 S153 Q291 C329 V330 T334 C335 P336 L337 N376 C378 R380

Gene Ontology

	Molecular Function
GO:0004783	sulfite reductase (NADPH) activity
GO:0016002	sulfite reductase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0050311	sulfite reductase (ferredoxin) activity
GO:0050661	NADP binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0000103	sulfate assimilation
GO:0008652	amino acid biosynthetic process
GO:0019344	cysteine biosynthetic process
GO:0070814	hydrogen sulfide biosynthetic process

	Cellular Component
GO:0009337	sulfite reductase complex (NADPH)

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6c3m, PDBe:6c3m, PDBj:6c3m
PDBsum	6c3m
PubMed	29852252
UniProt	P17846\|CYSI_ECOLI Sulfite reductase [NADPH] hemoprotein beta-component (Gene Name=cysI)

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