Structure of PDB 6c3l Chain A

Receptor sequence
>6c3lA (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
ADSQIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACS
GLFYSIFTDQLKRNLSVINLDPEINPEGFNILLDFMYTSRLNLRVGNIMA
VMATAMYLQMEHVVDTCRKFIKAS
3D structure
PDB6c3l Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design.
ChainA
Resolution1.46092 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EGP A M51 A52 C53 G55 Y58 E115 M47 A48 C49 G51 Y54 E111 MOAD: Kd=44uM
PDBbind-CN: -logKd/Ki=4.44,Kd=36uM
BindingDB: Kd=36000nM,IC50=27000nM
BS02 EGP A D17 N21 R28 D13 N17 R24 MOAD: Kd=44uM
PDBbind-CN: -logKd/Ki=4.44,Kd=36uM
BindingDB: Kd=36000nM,IC50=27000nM
External links
PDB RCSB:6c3l, PDBe:6c3l, PDBj:6c3l
PDBsum6c3l
PubMed29969259
UniProtP41182|BCL6_HUMAN B-cell lymphoma 6 protein (Gene Name=BCL6)

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