Structure of PDB 6c3e Chain A

Receptor sequence
>6c3eA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
VIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKIEHNEALLE
EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPL
SVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF
KMWSKLNNGTLYYMAPEHLPTEKSDVYSFAVVLWAIFANKEPYENAIAEQ
QLIMAIKSGNRPDVDDLTEYCPREIISLMKLCWEANPEARPTFPGIEEKF
RPFYLSQL
3D structure
PDB6c3e Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D126 K128 E130 N131 D144 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EJY A K45 L78 M92 L129 H136 A155 D156 S161 F162 K37 L66 M80 L117 H124 A143 D144 S149 F150 PDBbind-CN: -logKd/Ki=7.20,Ki=63.1nM
BindingDB: Ki=63nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6c3e, PDBe:6c3e, PDBj:6c3e
PDBsum6c3e
PubMed29485864
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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