Structure of PDB 6c2n Chain A

Receptor sequence
>6c2nA (length=198) [Search protein sequence]
HMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEG
EVQIVSTATQTFLATSINGVLWTVHHGAGTRTIASPKGPVTQMYTNVDKD
LVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRP
ISYLKGSSGGPLLCPAGHAVGIFRAAVSTRGVAKAVAFIPVESLETTM
3D structure
PDB6c2n Clinical signature variant of HCV NS3/4A protease uses a novel mechanism to confer resistance
ChainA
Resolution1.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 H1149 C116 C118 C164 H168
BS02 TSV A Q1041 F1043 H1057 D1081 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 Q60 F62 H76 D100 L154 K155 G156 S158 F173 R174 A175 A176
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6c2n, PDBe:6c2n, PDBj:6c2n
PDBsum6c2n
PubMed
UniProtA8DG50

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