Structure of PDB 6c0t Chain A

Receptor sequence
>6c0tA (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
EDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKT
FAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYM
LMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLK
PENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD
ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKN
AANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPI
IPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
3D structure
PDB6c0t Structural basis for selective inhibition of human PKG I alpha by the balanol-like compound N46.
ChainA
Resolution1.98 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D484 K486 N489 D502 T521
Catalytic site (residue number reindexed from 1) D148 K150 N153 D166 T185
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EE4 A V368 G369 G370 F371 G372 V374 A388 I406 M438 E439 A440 C441 E445 V501 D502 G504 V32 G33 G34 F35 G36 V38 A52 I70 M102 E103 A104 C105 E109 V165 D166 G168 MOAD: ic50=43.1nM
PDBbind-CN: -logKd/Ki=7.37,IC50=43.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6c0t, PDBe:6c0t, PDBj:6c0t
PDBsum6c0t
PubMed29769318
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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