Structure of PDB 6c0e Chain A

Receptor sequence

>6c0eA (length=419) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1)

SMTYDKIKVPAQGEAITVAADHSLHVPDNPIIPFIEGDGIGVDVTPPMIR
VVDAAVQKAYGNKRKISWMEVYAGEKATKVYGGDQWLPKETLDAMKKYVV
SIKGPLTTPVGGGIRSLNVAIRQDMDLYVCLRPIRYFNGVPSPVREPWKT
DMVIFRENSEDIYAGIEWQADTPEAKKVIQFLTKEMGVKKIRFPEHCGIG
VKPVSREGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTEGAFKDWGYQ
VARDSFGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYS
VIATLNLNGDYISDALAAQVGGIGIAPGANISDQMAVFEATHGTAPKYAG
QNKVNPGSIILSAEMMLRHMGWYEAADLIIRGMEGAIEAKTVTYDFERGM
QGATLVSSSGFADAMIKHM

3D structure

• PDB: 6c0e Crystal Structure of Isocitrate Dehydrogenase from Legionella pneumophila with bound NADPH with an ??-ketoglutarate adduct
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y166 K236 D289 D313
• Catalytic site (residue number reindexed from 1): Y163 K233 D286 D310
• Enzyme Commision number: 1.1.1.42: isocitrate dehydrogenase (NADP(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	EE1	A	P108 L109 T111 S119 N121 R125 R135 R159 D313 I326 E342 H345 G346 T347 A348 K350 Y351 V357 N358 Y397 D398	P105 L106 T108 S116 N118 R122 R132 R156 D310 I323 E339 H342 G343 T344 A345 K347 Y348 V354 N355 Y394 D395
BS02	GLY	A	S26 L27 H28	S23 L24 H25
BS03	EE1	A	N238 I287 Q294 R298	N235 I284 Q291 R295

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004450 isocitrate dehydrogenase (NADP+) activity
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0046872 metal ion binding
• GO:0051287 NAD binding

Biological Process

• GO:0006097 glyoxylate cycle
• GO:0006099 tricarboxylic acid cycle

External links

• PDB: RCSB:6c0e, PDBe:6c0e, PDBj:6c0e
• PDBsum: 6c0e
• UniProt: Q5ZXB6