Structure of PDB 6bz9 Chain A

Receptor sequence
>6bz9A (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSI
PRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKT
SDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDK
PKVIIIQACRGDSPGVVWFKD
3D structure
PDB6bz9 Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.
ChainA
Resolution1.796 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 R286
Catalytic site (residue number reindexed from 1) P51 R52 H111 G112 C159 R160
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R179 H237 Q283 C285 R53 H111 Q157 C159
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bz9, PDBe:6bz9, PDBj:6bz9
PDBsum6bz9
PubMed29891674
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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