Structure of PDB 6by8 Chain A

Receptor sequence
>6by8A (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSVPPVLTFQSEKMKGMKELLVATKI
NSSAIKLQLTAQSQVQMK
3D structure
PDB6by8 Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FNV A S155 S178 H181 F238 Y276 M278 M322 Y323 W341 E363 E366 S134 S157 H160 F217 Y255 M257 M301 Y302 W320 E342 E345 PDBbind-CN: -logKd/Ki=6.91,IC50=123nM
BindingDB: IC50=123nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6by8, PDBe:6by8, PDBj:6by8
PDBsum6by8
PubMed29738674
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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