Structure of PDB 6bxh Chain A

Receptor sequence
>6bxhA (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVN
RVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV
SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLR
DVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWL
YLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLG
HLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDV
IPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLH
VGWATFLVQSLGRFEGQVRQKVRIVSVPPVLTFQSEKMKGMKELLVATKI
NSSAIKLQLTAQSQVQMK
3D structure
PDB6bxh Menin in complex with MI-853
ChainA
Resolution2.445 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EE7 A S178 D180 H181 Y276 M278 M322 Y323 G326 C329 E363 S157 D159 H160 Y255 M257 M301 Y302 G305 C308 E342 BindingDB: IC50=10.0nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6bxh, PDBe:6bxh, PDBj:6bxh
PDBsum6bxh
PubMed
UniProtO00255|MEN1_HUMAN Menin (Gene Name=MEN1)

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