Structure of PDB 6bx6 Chain A

Receptor sequence
>6bx6A (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK
REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE
EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN
YAAPEYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP
EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLF
3D structure
PDB6bx6 AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D139 K141 E143 N144 D157
Catalytic site (residue number reindexed from 1) D127 K129 E131 N132 D145
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.31: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EDJ A L22 G23 A43 V96 G99 A156 L10 G11 A31 V84 G87 A144 PDBbind-CN: -logKd/Ki=6.48,IC50=0.33uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6bx6, PDBe:6bx6, PDBj:6bx6
PDBsum6bx6
PubMed29695504
UniProtP54646|AAPK2_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Gene Name=PRKAA2)

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