Structure of PDB 6bwa Chain A

Receptor sequence

>6bwaA (length=416) Species: 9606 (Homo sapiens) [Search protein sequence]

SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQFFSS

3D structure

PDB

6bwa Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	S100 R103 F133 W137 N141 S144 G145 T150 Q176 W179 N183 G186 D187 W222 N226 R229 W264 T302 R306 V312 G314 D316 T319 E345 W348 N352 E387 W390 S393 N394 I397	S29 R32 F62 W66 N70 S73 G74 T79 Q105 W108 N112 G115 D116 W151 N155 R158 W193 T231 R235 V241 G243 D245 T248 E274 W277 N281 E316 W319 S322 N323 I326

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6bwa, PDBe:6bwa, PDBj:6bwa
PDBsum	6bwa
PubMed	30209309
UniProt	O00629\|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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