Structure of PDB 6bw5 Chain A

Receptor sequence
>6bw5A (length=378) Species: 9606 (Homo sapiens) [Search protein sequence]
PMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPES
QGVISGAVFLIILFCFIPFPFLNCAFPHHEFVALIGALLAICCMIFLGFA
DDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIHLDLGILYYVYMGLL
AVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSLY
FMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTML
LFFMPQVFNFLYSLPQLLHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKSL
SFLGTFILKVAESLQLVTVHQSETEDGEFTECNNMTLINLLLKVLGPIHE
RNLTLLLLLLQILGSAITFSIRYQLVRL
3D structure
PDB6bw5 GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.15: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TUM A L46 N119 W122 K125 L126 F179 N182 N185 A188 G189 I190 N191 F249 D252 H302 R303 L39 N105 W108 K111 L112 F153 N156 N159 A162 G163 I164 N165 F223 D226 H276 R277 PDBbind-CN: -logKd/Ki=8.25,Kd=5.6nM
BS02 PGW A C107 F110 L111 A114 H124 C93 F96 L97 A100 H110
BS03 PGW A A31 F32 H35 I68 A24 F25 H28 I61
Gene Ontology
Molecular Function
GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0019348 dolichol metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bw5, PDBe:6bw5, PDBj:6bw5
PDBsum6bw5
PubMed29459785
UniProtQ9H3H5|GPT_HUMAN UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (Gene Name=DPAGT1)

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